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Healthy Ingredients


L-Citrulline an AquaArgi ingredient is bursting onto the fitness scene in a big way, helping people young and old break through the boundaries of personal health and fitness.

Amino acids are nitrogen-containing molecules used by your cells to perform a wide variety of tasks. Their most prominent role is in the manufacture of proteins, which serve as structural elements, enzymes, transport and storage molecules, antibodies and hormones. L-citrulline helps your cells eliminate waste products, and it enhances the production of nitric oxide, a gas that is involved in many physiologic processes. L-citrulline malate is a supplemental form of this important amino acid.

Essential versus Non-Essential

Your body uses 22 naturally occurring amino acids to accomplish its myriad metabolic tasks. Ten of these amino acids cannot be synthesized in your cells and must be acquired from your diet. The remainder can be manufactured from other compounds in healthy, well-nourished adults. According to Elson Haas, M.D., author of “Staying Healthy with Nutrition – The Complete Guide to Diet and Nutritional Medicine,” your cells make L-citrulline by combining L-ornithine, another amino acid, with ammonia and carbon dioxide. Most people make enough L-citrulline for their needs, but athletes and others may benefit from supplementation.

Ammonia Cycling

Cellular metabolism normally generates waste products that must be eliminated from your body. The breakdown of proteins creates toxic ammonia, which must be converted to a nontoxic, water-soluble compound called urea so it can be transported through your bloodstream and eliminated through your kidneys. As part of the urea cycle, L-citrulline plays a pivotal role in removing ammonia from your tissues. In 2011, scientists at Japan’s University of Tsukuba showed that supplementation with L-citrulline improved endurance in exercised laboratory animals. In contrast, supplementation with L-arginine and L-ornithine, two other components of the urea cycle, does not improve endurance.

Nitric Oxide

L-arginine and L-citrulline are chemically related amino acids, and they are frequently converted back and forth in your cells. However, the conversion from L-arginine to L-citrulline requires a different metabolic pathway than the conversion from L-citrulline to L-arginine. The conversion of citrulline to arginine utilizes a pathway that first produces ornithine. The arginine-to-citrulline conversion is more direct and produces a molecule of nitric oxide. One of nitric oxide’s many effects is to dilate your arteries, which improves blood flow to exercising muscles. It is believed that supplementation with L-citrulline increases arginine synthesis, which in turn enhances nitric oxide production.


Supplementation with L-citrulline malate could improve exercise performance through two mechanisms. By facilitating removal of ammonia from exercising muscles, citrulline enhances cellular metabolism, improves energy production and extends exercise times. By increasing nitric oxide production, citrulline improves blood flow, which not only delivers more oxygen and nutrients to metabolically active tissues, but also hastens the removal of waste products. The optimal dosage of L-citrulline malate for exercise enhancement has not been determined, but daily doses of 3 to 6 grams have been used in human studies. If you have a medical condition, ask your doctor if you should take amino acid supplements.

The French Paradox: Resveratrol, a compound found in red wine, first gained publicity in the early nineties when the CBS television show, 60-Minutes, investigated why people living in France, despite eating diets high in saturated fats, had lower rates of coronary heart disease than people living in the United States. The report concluded that a higher consumption of red wine may play a role in lowering coronary heart disease. Since then, research has pointed to resveratrol, a substance contained in grape skins and many other plants, as the compound with the possibility of preventing or delaying coronary heart disease, in addition to various other health benefits

Regular Vitamin B-12 supplements must be converted in the body to Methylcobalamin before they can provide any benefits – Methylcobalamin supplements allow you to bypass this step for quicker absorption

You may not be able to absorb B-12 as well as you get older, so mature adults may especially benefit from a Methylcobalamin supplement**

Having problems with your blood sugar? Then you may be chromium deficient. Chromium is an essential trace element that plays a role in blood sugar metabolism by enhancing insulin’s effects and assisting in the thousands of necessary chemical reactions that occur in your body. Some studies have also suggested that it may help you gain muscle and lose fat.

Chromium is naturally found in small amounts in foods like broccoli, romaine lettuce and meat. One of the strongest sources of chromium is whole grains; however, after grains are processed into foods like white bread or white rice, the majority of the chromium is lost.

How Does It Work?

It’s unclear how it works exactly to lower blood sugar; however, some experts believe it works on insulin receptors, enhancing its effects on the body and lowering blood sugar levels. Some studies suggest that it can also increase the number of insulin receptors in the body, making it more effective at lowering blood sugar.

Is It Effective?

Studies have found that supplemental chromium can improve the signs and symptoms of diabetes and help insulin resistance.

With regard to fat loss, another study on 20 overweight women found that taking chromium polynicotinate contributed to more fat loss with less muscle loss.

Astragin Enhances the absorption of key amino acids, vitamins, and minerals by up to 66%

Brain health dramatically improved by intake of omega-3 fatty acids